<p>4:22 <i>The Lord be with your spirit. Grace be with you</i>- As noted on 1:14 and elsewhere, Paul was very conscious of the work of the Spirit as an internal strengthening within Timothy's spirit. &quot;Grace&quot; or 'gift', <i>charis</i>, refers to the gift of the Spirit; so we see here the way Lord's Spirit intertwines with the human spirit. This is Paul's closing wish to Timothy, because he realized the supreme importance of having the mind or spirit of Christ. We should give it a like importance.</p>